Circuits of coGnitive Systems
Working memory, the capacity to temporarily hold multiple pieces of information in mind for manipulation, is central to almost all cognitive abilities. Many mental diseases, including Alzheimer’s, schizophrenia, dementia, bipolar depression, autism, and attention deficit/hyperactivity disorder, involve working memory.
BRAIN CoGS is a 7-lab NIH-funded project, based at Princeton and UC Davis, that aims to determine how the brain produces decisions based on working memory. We are using a coordinated effort across all our labs to observe, map, perturb, and model brain circuits with state-of-the-art technologies. Our goal is for this work to lead to a major advance in basic science, that will in turn provide critical clues to therapeutic approaches.