Sebastian Seung, David Tank, Jonathan Pillow, Adrian Wanner, Mark Ioffe, Alexander Riordan, Zhihao Zheng
Working memory, the ability to temporarily hold multiple pieces of information in mind for manipulation, is central to virtually all cognitive abilities. This multi-component research project aims to comprehensively dissect the neural circuit mechanisms of this ability across multiple brain areas. The overall goal of this project is to combine in-vivo functional imaging in mice performing working memory tasks in a virtual-reality setting with subsequent large-scale electron microscopy based circuit reconstruction. The reconstructed activity and connectivity patterns will be used to develop a neural circuit model of working memory and decision-making across multiple brain regions, constrained by neural activity, inactivation results, and connectivity.